The final product is an aromatic hydroxy acid which is also known as salicylic acid the precursor to aspirin. By using potassium hydroxide , 4-hydroxybenzoic acid is accessible, an important precursor for the versatile paraben class of biocides used e. The methodology is also used in the industrial synthesis of 3-hydroxynaphthoic acid. The regiochemistry of the carboxylation in this case is sensitive to temperature.

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Kolbe-Schmitt reaction

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. The combined use of an organic base for resorcinols realized a Kolbe—Schmitt type reaction under ambient conditions. When resorcinols 3-hydroxyphenol derivatives were treated with DBU under a carbon dioxide atmosphere, nucleophilic addition to carbon dioxide proceeded to afford the corresponding salicylic acid derivatives in high yields.


Kolbe Reaction Mechanism (Kolbe Schmitt Reaction)


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