Jejunal diverticulosis as cause of gastrointestinal hemorrhages : Case report. Chile [online]. ISSN Jejunal diverticulosis is a very uncommon acquired disease.
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Diverticulosis and Diverticulitis. In diverticulitis, one or a few of the Dietary pattern and colonic diverticulosis. To assess the role of dietary pattern on the occurrence of colonic diverticulosis , diverticular disease and acute diverticulitis.
No association was seen between nut, corn or popcorn consumption and occurrence of diverticulosis , diverticular disease and acute diverticulitis. It seems to be a mild association between high alcohol intake and diverticulosis occurrence, whereas alcohol dependence seems to show lower risk of in-hospital mortality due to acute diverticulitis.
Higher red-meat consumption shows mild increased risk of acute diverticulitis, especially when consumed as unprocessed red meat defined as consumption of 'beef or lamb as main dish', 'pork as main dish', 'hamburger' and 'beef, pork or lamb as a sandwich or mixed dish' ; higher consumption of poultry viz. Finally, higher fish intake was associated with reduced risk of diverticulitis in age-adjusted model, but not after further adjustment for other potential confounders.
Current literature data about the role of dietary pattern on the occurrence of colonic diverticulosis , diverticular disease and acute diverticulitis are still too conflicting. Animal Models of Diverticulosis : Review and Recommendations. Diverticulosis is a structural alteration of the colon tissue characterized by the development of pouch-like structures called diverticula.
It afflicts a significant portion of the population in Western countries, with a higher prevalence among the elderly. Diverticulosis is believed to be the result of a synergetic interaction between inherent tissue weakness, diet, colonic microstructure, motility, and genetic factors. A validated etiology has, however, not yet been established. Non-surgical treatment is currently lacking due to this poor understanding, and surgical colon resection is the only long-term solution following recurrent complications.
With rising prevalence, the burden of diverticulosis on patients and hospital resources has increased over the past several years. More efficient and less invasive treatment approaches are, thus, urgently needed. Animal models of diverticulosis are crucial to enable a preclinical assessment and evaluation of such novel approaches.
This review discusses the animal models of diverticulosis that have been proposed to date. The current models require either a significant amount of time to develop diverticulosis , present a relatively low success rate, or seriously deteriorate the animals' systemic health. Recommendations are thus provided to address these pitfalls through the selection of a suitable animal and the combination of multiple risk factors for diverticulosis. Diverticular disease of the colon. Sleisenger and Fordtran's Gastrointestinal and Liver Disease.
Philadelphia, PA: Elsevier Pathogenesis of diverticulosis and diverticular disease. Diverticulosis is defined by the presence of diverticula due to herniation of mucosa and muscularis mucosa through the muscularis propria at sites of vascular penetration in the colon and is asymptomatic in the vast majority affected.
There are global differences of distribution, in Western industrialized societies, the most common site is in the left colon, but in Asia right sided diverticulosis predominates. Whilst present in Diverticular disease is defined as clinically significant and symptomatic diverticulosis , which may have an absence of macroscopically overt colitis and in true diverticulitis there is macroscopic inflammation of diverticula with related acute or chronic complications.
Diverticulosis is one of the most common chronic diseases, yet research in this field on pathogenesis has lagged behind other common conditions such as diabetes mellitus. However, in the last decade there have been major advances in taxonomy that can be used to relate to patients' outcome and treatment in both medicine and surgery.
It has been shown there is an association with age, diet, drugs and smoking. Genetic studies have shown a familial association and a specific gene, TNFSF 15 may predict severity of disease. The role of the microbiome has been explored and microbial and metabolomic signatures are also important in predicting disease severity. That diverticulosis is a chronic disease is shown by mucosal pathology with subtle chronic inflammation present in those with asymptomatic diverticulosis and inflammation may lead to muscular hypertrophy, enteric nerve remodeling with disordered motility.
The diverticulitis quality of life instrument shows that this condition impacts markedly on patients' well-being and prevention and. Diverticulosis and its complications are important healthcare problems in the USA and throughout the Western world.
While mechanisms as to how diverticulosis occurs have partially been explored, few studies examined the relationship between colonic gases such as methane and diverticulosis in humans. This study aimed to demonstrate a significant relationship between methanogenic Archaea and development of diverticulosis.
Subjects who consecutively underwent hydrogen breath test at Rush University Medical Center between and were identified retrospectively through a database. Medical records were reviewed for presence of a colonoscopy report. Two hundred and sixty-four subjects were identified who had both a breath methane level measurement and a colonoscopy result.
Additional demographic and clinical data were obtained with chart review. Mean breath methane levels were higher in subjects with diverticulosis compared to those without diverticulosis 7. When adjusted for confounders, breath methane levels and age were the two independent predictors of diverticulosis on colonoscopy with logistic regression modeling.
Methanogenesis is associated with the presence of diverticulosis. Further studies are needed to confirm our findings and prospectively evaluate a possible etiological role of methanogenesis and methanogenic archaea in diverticulosis. PubMed Central. Jejunal diverticulosis is generally asymptomatic and is associated with high morbidity and mortality secondary to complications, especially in elderly patients.
We present a case report of a year-old female patient with jejunal diverticulosis and perforation due to diverticulitis. A rare cause of acute abdomen: jejunal diverticulosis with perforation. Electromanometry of the rectosigmoid in colonic diverticulosis. In order to better understand the rectosigmoid motor activity in diverticular disease of the colon, we studied patients, grouped according to their intestinal habit, the presence of diverticular disease and previous crisis of sigmoid diverticulitis.
The intestinal habit was classified as: normal habit, irritable colon syndrome, diarrhea and constipation. The group of diverticulosis was classified by their intestinal habit and by diverticula localization localized or generalized. The presence of systemic diseases or drug ingestion that could modify intestinal motility, were considered criteria for exclusion.
The manometric study was preceded by food stimulus, with kcal meal, by mechanic intestinal cleansing, with ml of saline solution enema and by one hour resting period. A manometric catheter, was introduced by rectosigmoidoscopy, with open ended orifices situated at the sigmoid and upper rectum, respectively.
The catheter was perfused by a capillary infusion system and the bowel pressures were registered for 30 minutes, in a thermal paper physiograph.
No significant difference was observed between sexes. Difference or close to it were found for the groups with constipation, with or without diverticulosis , and for the latter in its subdivisions localized, generalized and sigmoid diverticulitis. The rectal motor activity was similar in all groups. There was no difference for diverticulosis and its subdivision, when we take into account the several kinds of intestinal habits and the diverticula localization.
The motility index averages showed low values for the sigmoid diverticulitis fact that suggests some dysfunction of this segment hypocontractility. The key factor differentiating the groups was the presence of constipation and no influence was noted regarding the localization of diverticula or previous inflammatory process on intraluminal pressures. Colonic diverticulosis is not a risk factor for colonic adenoma. Colonic diverticulosis may represent a risk factor for colonic adenomas by virtue of the fact that evolving data suggest that these 2 conditions may share common risk factors such as Western dietary pattern and physical inactivity.
This study aims to investigate the association between colonic diverticulosis and colonic adenomas in mainland China. We conducted a cross-sectional study on patients who underwent colonoscopic examination between October and December in a university hospital in mainland China.
Age, gender, colonic adenomas, advanced adenomas, and distribution of diverticulosis were recorded during the procedures. Multivariate logistic regression and stratified analysis were used to evaluate the associations between the prevalence of diverticulosis and age, sex, and presence of colonic adenomas and advanced adenomas. A total of 17, subjects were enrolled.
The prevalence of colonic diverticulosis and adenoma was 2. Multiple logistic regression analysis suggested that age and male gender were independent risk factors for adenoma and advanced adenoma. There was no relationship between diverticulosis or location of diverticulosis and presence of adenoma and advanced adenoma adjusting by age and gender. In a stratified analysis according to age and gender, similar results were also noted. There was no statistical relationship between diverticulosis and the risk of adenoma and advanced adenoma.
Our results may not be generalized to the Western population due to the fact that left-sided diverticular cases were very small in our study. Pattern and distribution of colonic diverticulosis : analysis of barium enemas in Thailand.
To determine the pattern and distribution of colonic diverticulosis in Thai adults. The pattern and distribution of colonic diverticulosis detected during DCBE studies from June to October were determined. The occurrence of solitary cecal diverticulum, rectal diverticulum and giant diverticulum were reported. Factors influencing the presence of colonic diverticulosis were evaluated.
A total of suitable DCBE examinations were retrospectively reviewed. The mean age of patients was Of these patients, Colonic diverticulosis was identified in patients Right-sided diverticulosis cases; Pancolonic diverticulosis was found in 98 cases 3. The occurrence of solitary cecal diverticulum, rectal diverticulum and giant diverticulum were 1.
There was no significant difference in the overall occurrence of colonic diverticulosis between male and female patients DCBE examinations performed in patients with some gastrointestinal symptoms revealed the frequent occurrence of colonic diverticulosis compared with those performed in asymptomatic individuals Change in bowel habit was strongly associated with the presence of diverticulosis a relative risk of 1. Colonic diverticulosis was identified in No neuronal loss, but alterations of the GDNF system in asymptomatic diverticulosis.
Glial cell line-derived neurotrophic factor GDNF is a potent neurotrophic factor known to promote the survival and maintenance of neurons not only in the developing but also in the adult enteric nervous system. As diverticular disease DD is associated with reduced myenteric neurons, alterations of the GDNF system were studied in asymptomatic diverticulosis diverticulosis and DD.
Morphometric analysis for quantifying myenteric ganglia and neurons were assessed in colonic full-thickness sections of patients with diverticulosis and controls. Myenteric protein expression of both receptors was quantified by fluorescence-immunohistochemistry of patients with diverticulosis , DD, and controls.
Perforated Jejunal Diverticulum: A Rare Complication
Jejunal and ileal diverticula are rare in adults. Duodenal diverticula are five times more prevalent than jejunoileal diverticula. Most patients are asymptomatic. Gastric cancer is the second most common cancer in South Korea and here we report a case of early gastric cancer with multiple duodenal and jejunal diverticula. A year-old woman was admitted to Konkuk University Medical Center with chronic diarrhea and weight loss of 19 kg over 2 months. Following gastroduodenoscopy, we identified adenocarcinoma of the lower body of the stomach.
Small bowel diverticulosis in patient with early gastric cancer
Jejunoileal diverticula , also referred to as jejunal diverticula or diverticulosis as most of the diverticula are located in the jejunum , are outpouchings from the jejunal and ileal wall on their mesenteric border that represent mucosal herniation through sites of wall weakening 1. Please refer to the articles on duodenal diverticula and on Meckel diverticulum for a discussion of other small intestine diverticular disease. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Updating… Please wait. Unable to process the form. Check for errors and try again. Thank you for updating your details.