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Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction. The chemotherapy agents against cancer may be classified as " cell cycle-specific" or " cell cycle-nonspecific". The earliest and perhaps most extensively studied and most heavily employed clinical anticancer agents in use today are the DNA inter-strand cross-linking agents. Nesta fase, o DNA apresenta-se super-enovelado, com atividade nuclear baixa. Ligantes na fenda menor. Spence, R.

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Seus pacientes merecem sempre o melhor. Por isso, conte com a linha completa de produtos da ReSound. Surpreenda seus pacientes com os aparelhos auditivos ReSound. Visite agora mesmo: www. Cuidado completo. CNPJ Rua Alberto Correia Francfort, Embu das Artes-SP.

Gel nasal contendo 1 frasco aplicador em frascos com 10 g ou 30 g. Bula do medicamento. Bula do Medicamento. TANO, L. A daily nasal spray with saline prevents symptoms of rhinitis. Acta Otolaryngol. MION, O. Nasal saline irrigation in children: a study of compliance and tolerance. The role of nasal mucus in upper airways function. In: SIH, T. Pediatric nasal and sinus disorders: lung biology in health and disease.

Book Head Neck Surg. Editorial comments should be sent to journals thieme. Articles may be submitted to this journal on an open-access basis. For further information, please send an e-mail to openaccess thieme. The content of this journal is available online at www. Visit our Web site at www. Thieme Medical Publishers is a member of the CrossRef initiative. Some of the product names, patents, and registered designs referred to in this publication are in fact registered trade marks or proprietary names even though specific reference to this fact is not always made in the text.

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Although all advertising material is expected to conform to ethical medical standards, inclusion in this journal does not constitute a guarantee or endorsement of the quality or value of such product or of claims made by its manufacturer. Medicine is truly a unique art and is undoubtedly the synthesis of a triple humanizing and ethical role, translated as personally helping older colleagues perform a therapeutic act and teaching younger ones to do the same.

Miniti attending one of many congresses along side with Prof. Alexandre Medicis da Silveira and Prof. Ricardo Bento. Otorhinolaryngology, ISSN Miniti with Prof. Professor in The technique of using dura mater was practiced for many years in Brazil. An outstanding ear surgeon, he leaves behind a teaching legacy in HC and in Brazil, after teaching hundreds of surgeons not only the art of medicine but, most importantly, the ethical and moral principles of the profession.

A disciplinarian, but with a big heart, Professor Aroldo was revered by the medical residents and assistants and held in high esteem by otorhinolaryngologists from across the country. Despite his generosity, he always imposed strict discipline at the workplace, but strived to ease differences and maintain harmony in the Clinic.

The unique aspect of this clinic was to. Miniti in with colleagues. Otorhinolaryngology was experiencing a golden moment with the expansion of its areas of action beyond the classic ear, nose, and throat to sleep medicine, facial plastic surgery, facial nerve diseases, and electrophysiology and modern otoneurology. This was a worldwide phenomenon. In the career history book of Dr. Choose something else. In such a context, Professor Aroldo proved his worth by initiating the development of the sub-areas of the specialty.

Professor Aroldo was one of the founders of the International Archives of Otorhinolaryngology and was part of its Editorial Board for several years. Sadly, Professor Aroldo, our dear master, is no longer with us today and his journey has ended. More important than the sadness of this moment is the knowledge that the path he showed us still bears the fruits, wisdom, and teachings of his life.

Professor Aroldo, thank you for everything! Objective This study aims to investigate the relationship between menstrual cycle and outer hair cell function with audiological examination. Methods This is an analytic study with a cross-sectional design. The sampling was a systematic random sampling. We found 49 women with normal menstrual cycle and collected their data through interviews, physical examination, and examination of the ear, with otoscopic and other routine otorhinolaryngology examinations.

In other words, we found no correlation between menstrual and audiometry threshold. Introduction Some researchers have proposed that women with hormonal changes may experience alterations in auditory functions, such as in menopause woman, woman with hormonal contraceptive, or even during the ovarian cycle. Previous studies. Changes in sodium and water reabsorption that take place during the ovarian cycle may.

Influence of Hormonal Changes in Normal Ovarian Cycle Females affect the functioning of this part of the peripheral auditory system, which could in turn affect homeostasis, causing auditory and labyrinthic symptoms. It is more variable in length than the other phases. Then, estrogen levels begin to rise until about day 13 to 14, when ovulation occurs.

Estrogen reaches its peak level just before ovulation. It does not vary much from month to month. In this phase, blood supply to the endometrium continues to increase due to the rising level of progesterone produced by the corpus luteum of the ovary, reaching its highest level around day 7, after ovulation.

High progesterone may increase sodium, chloride, and water reabsorption. Changes in sodium and water reabsorption that take place during the ovarian cycle may affect the function of this part of peripheral auditory system.

Nonetheless, there has not been a reliable solution. Material and Methods Subjects This is an analytic study with a cross-sectional design.

We recruited forty-nine patients of reproductive age 20 to 40 years old by systematic random sampling from the entire population of residents at Adam Malik General Hospital in North Sumatera, Indonesia, with an interval of The Health Research Ethical Committee granted approval for the study. All women reported a regular menstrual cycle ranging between 24 and 35 days.

We documented positive LH surge. None of the women had been taking hormonal contraceptive or other drug treatment that could alter their auditory function such as Cisplatin, aminoglycoside, hemodialysis. They had no history of endocrine pathology, hypertension, or otological conditions. All women had normal otoscopy, normal hearing and middle ear function, assessed by pure tone audiometry and tympanometry.

During each test session, the subjects underwent auditory tests including audiometry, tympanometry, and DPOAE. Material The same audiologist performed each test.

For pure tone audiometry, to assess the hearing threshold, the audiologist used Audio Traveler AA Interacoustics, Denmark. The tone pulses were 1—2 seconds in duration to avoid adaptation with ascending sound technique, according to the recommendation from the American Speech-language Hearing Association.

We excluded patients with conductive hearing loss. The patients underwent tympanometry to determine the function of middle ear. The peak value of compliance was in the range between 0. This indicated good tympanic membrane mobility and normal middle ear pressure, enabling a valid otoacoustic emission recording. Signal-to-noise ratio had to be 3 dB or higher at each frequency. The device used in this test was the Elios Echodia, France.

Using the paired sample t-test, we observed the effect of the menstrual cycle phase on OAE and audiometry. International Archives of Otorhinolaryngology. Result The sample consisted of 49 women of reproductive age.

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